منابع مشابه
Virus meets RNAi
Introduction Small rnas are important regulators of gene expression that operate through a range of rna-silencing mechanisms. of these, rna interference (rnai)—gene silencing through small-interfering rnas (sirnas) derived from exogenous double-stranded rna (dsrna)—and the microrna (mirna) pathway—gene silencing guided by small rnas encoded in the genome—are the best known. the discovery that d...
متن کاملThe DNA virus Invertebrate iridescent virus 6 is a target of the Drosophila RNAi machinery.
RNA viruses in insects are targets of an RNA interference (RNAi)-based antiviral immune response, in which viral replication intermediates or viral dsRNA genomes are processed by Dicer-2 (Dcr-2) into viral small interfering RNAs (vsiRNAs). Whether dsDNA virus infections are controlled by the RNAi pathway remains to be determined. Here, we analyzed the role of RNAi in DNA virus infection using D...
متن کاملRNAi Targeting of West Nile Virus in Mosquito Midguts Promotes Virus Diversification
West Nile virus (WNV) exists in nature as a genetically diverse population of competing genomes. This high genetic diversity and concomitant adaptive plasticity has facilitated the rapid adaptation of WNV to North American transmission cycles and contributed to its explosive spread throughout the New World. WNV is maintained in nature in a transmission cycle between mosquitoes and birds, with i...
متن کاملAsian Citrus Psyllid RNAi Pathway – RNAi evidence
Diaphorina citri, known as the Asian citrus psyllid, is an important pest of citrus because it transmits a phloem-limited bacteria strongly implicated in huanglongbing (citrus greening disease). Emerging biotechnologies, such as RNA interference, could provide a new sustainable and environmentally friendly strategy for the management of this pest. In this study, genome and functional analysis w...
متن کاملRole of RNA interference (RNAi) in dengue virus replication and identification of NS4B as an RNAi suppressor.
RNA interference (RNAi) is an important antiviral defense response in plants and invertebrates; however, evidences for its contribution to mammalian antiviral defense are few. In the present study, we demonstrate the anti-dengue virus role of RNAi in mammalian cells. Dengue virus infection of Huh 7 cells decreased the mRNA levels of host RNAi factors, namely, Dicer, Drosha, Ago1, and Ago2, and ...
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ژورنال
عنوان ژورنال: EMBO reports
سال: 2008
ISSN: 1469-221X,1469-3178
DOI: 10.1038/embor.2008.133